Corpus ID: 38912674

Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta.

  title={Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta.},
  author={Leah Jaffe and Lucie Jeannotte and Elizabeth K. Bikoff and Elizabeth J. Robertson},
  journal={Journal of immunology},
  volume={145 10},
The major transplantation (MHC) Ag in the mouse are cell-surface glycoproteins composed of a 40- to 45-kDa H chain and a 12-kDa L chain, beta 2-microglobulin (beta 2 m). Regulation of MHC gene expression during early development is thought to play a critical role in maternal tolerance of the fetal allograft. We have used in situ hybridization techniques to characterize the temporal and spatial pattern of expression of the beta 2 m gene in the developing mouse embryo. beta 2 m mRNA is first… Expand
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