Analysis of axonal regeneration in the central and peripheral nervous systems of the NG2-deficient mouse

@article{HossainIbrahim2007AnalysisOA,
  title={Analysis of axonal regeneration in the central and peripheral nervous systems of the NG2-deficient mouse},
  author={Mohammed K Hossain-Ibrahim and Kia Rezajooi and William B Stallcup and Alexander R Lieberman and Patrick Anderson},
  journal={BMC Neuroscience},
  year={2007},
  volume={8},
  pages={80 - 80}
}
The chondroitin sulphate proteoglycan NG2 blocks neurite outgrowth in vitro and has been proposed as a major inhibitor of axonal regeneration in the CNS. Although a substantial body of evidence underpins this hypothesis, it is challenged by recent findings including strong expression of NG2 in regenerating peripheral nerve. We studied axonal regeneration in the PNS and CNS of genetically engineered mice that do not express NG2, and in sex and age matched wild-type controls. In the CNS, we used… CONTINUE READING