Analysis of apoptotic and survival mediators in the early post-natal and mature retina.

@article{ODriscoll2006AnalysisOA,
  title={Analysis of apoptotic and survival mediators in the early post-natal and mature retina.},
  author={Carolyn O'Driscoll and Maryanne Donovan and Thomas G Cotter},
  journal={Experimental eye research},
  year={2006},
  volume={83 6},
  pages={1482-92}
}
Apoptosis, a cellular process critical to retinal neurogenesis, has been implicated in several neurodegenerative disorders. As the retina matures the suppression of apoptosis occurs and the emphasis shifts towards survival. To identify the cellular changes that bring about this critical shift in the balance, we performed an expression analysis of pro- and anti-apoptotic mediators in the immature, post-natal day 6 (P6) and the post-mitotic adult P60 mouse retina. Laser capture microdissection… CONTINUE READING

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Laser capture microdissection ( LCM ) of the P6 and the P60 retina , followed by reverse transcriptase - polymerase chain reaction ( RT - PCR ) was employed to elucidate changes in the mRNA expression of Apaf-1 , caspase-3 and caspase-9 in the individual retinal layers in the young and mature tissue .
Laser capture microdissection ( LCM ) of the P6 and the P60 retina , followed by reverse transcriptase - polymerase chain reaction ( RT - PCR ) was employed to elucidate changes in the mRNA expression of Apaf-1 , caspase-3 and caspase-9 in the individual retinal layers in the young and mature tissue .
Our results demonstrate that each neuronal cell layer in the adult retina down - regulates the gene expression of Apaf-1 and caspase-3 , and to a lesser extent , caspase-9 .
Laser capture microdissection ( LCM ) of the P6 and the P60 retina , followed by reverse transcriptase - polymerase chain reaction ( RT - PCR ) was employed to elucidate changes in the mRNA expression of Apaf-1 , caspase-3 and caspase-9 in the individual retinal layers in the young and mature tissue .
Our results demonstrate that each neuronal cell layer in the adult retina down - regulates the gene expression of Apaf-1 and caspase-3 , and to a lesser extent , caspase-9 .
Laser capture microdissection ( LCM ) of the P6 and the P60 retina , followed by reverse transcriptase - polymerase chain reaction ( RT - PCR ) was employed to elucidate changes in the mRNA expression of Apaf-1 , caspase-3 and caspase-9 in the individual retinal layers in the young and mature tissue .
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