Analysis of antibody diversity: V-D-J mRNA nucleotide sequence of four anti-GAT monoclonal antibodies. A paucigene system using alternate D-J recombinations to generate functionally similar hypervariable regions.

@article{ROCCASERRA1983AnalysisOA,
  title={Analysis of antibody diversity: V-D-J mRNA nucleotide sequence of four anti-GAT monoclonal antibodies. A paucigene system using alternate D-J recombinations to generate functionally similar hypervariable regions.},
  author={JOSt ROCCA-SERRA and H. W. Matthes and Matti Kaartinen and C{\'e}sar Milstein and Jacques Th{\'e}ze and Michel Fougereau},
  journal={The EMBO journal},
  year={1983},
  volume={2 6},
  pages={867-72}
}
The nucleotide sequence of four anti-(Glu60-Ala30-Tyr10)n (GAT) monoclonal gamma 1 heavy chain mRNAs was determined from codon 10 to 120. This sequence overlaps with the NH2-terminal amino acid sequence, allowing elucidation of the complete protein sequence encompassing regions VH, D and JH. These sequences, which are highly conserved, indicate that anti-GAT antibodies expressing the same public idiotypic specificities represent a paucigene system, which uses at least two D-J combinations… CONTINUE READING

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