Analysis of ancient sequence motifs in the H+‐PPase family

@article{Hedlund2006AnalysisOA,
  title={Analysis of ancient sequence motifs in the H+‐PPase family},
  author={Joel Hedlund and Roberto Cantoni and Margareta Baltscheffsky and Herrick Baltscheffsky and Bengt Persson},
  journal={The FEBS Journal},
  year={2006},
  volume={273}
}
The unique family of membrane‐bound proton‐pumping inorganic pyrophosphatases, involving pyrophosphate as the alternative to ATP, was investigated by characterizing 166 members of the UniProtKB/Swiss‐Prot + UniProtKB/TrEMBL databases and available completed genomes, using sequence comparisons and a hidden Markov model based upon a conserved 57‐residue region in the loop between transmembrane segments 5 and 6. The hidden Markov model was also used to search the approximately one million… 

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