Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation

@inproceedings{Grimmer2014AnalysisOA,
  title={Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation},
  author={Matthew R. Grimmer and Sabine Stolzenburg and Ethan Ford and Ryan Lister and Pilar Blancafort and Peggy J. Farnham},
  booktitle={Nucleic acids research},
  year={2014}
}
Artificial transcription factors (ATFs) and genomic nucleases based on a DNA binding platform consisting of multiple zinc finger domains are currently being developed for clinical applications. However, no genome-wide investigations into their binding specificity have been performed. We have created six-finger ATFs to target two different 18 nt regions of the human SOX2 promoter; each ATF is constructed such that it contains or lacks a super KRAB domain (SKD) that interacts with a complex… CONTINUE READING
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