Analysis of alternative splicing associated with aging and neurodegeneration in the human brain.

@article{Tollervey2011AnalysisOA,
  title={Analysis of alternative splicing associated with aging and neurodegeneration in the human brain.},
  author={James R. Tollervey and Zhen Wang and Tibor Hortob{\'a}gyi and Joshua T. Witten and Kathi Zarnack and Melis Kayikci and Tyson Clark and Anthony C. Schweitzer and Gregor Rot and Toma{\vz} Curk and Blaz Zupan and Boris Rogelj and Christopher E. Shaw and Ule Jernej},
  journal={Genome research},
  year={2011},
  volume={21 10},
  pages={1572-82}
}
Age is the most important risk factor for neurodegeneration; however, the effects of aging and neurodegeneration on gene expression in the human brain have most often been studied separately. Here, we analyzed changes in transcript levels and alternative splicing in the temporal cortex of individuals of different ages who were cognitively normal, affected… CONTINUE READING
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