Analysis of alternative signaling pathways of endoderm induction of human embryonic stem cells identifies context specific differences

Abstract

Lineage specific differentiation of human embryonic stem cells (hESCs) is largely mediated by specific growth factors and extracellular matrix molecules. Growth factors initiate a cascade of signals which control gene transcription and cell fate specification. There is a lot of interest in inducing hESCs to an endoderm fate which serves as a pathway towards… (More)
DOI: 10.1186/1752-0509-6-154

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