Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

  title={Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.},
  author={Manel Esteller and Amy Sparks and Mieko Toyota and Montserrat S{\'a}nchez-C{\'e}spedes and Gabriel Capell{\'a} and Miguel A. Peinado and Susana Gonz{\'a}lez and Gemma Tarafa and David Sidransky and Stephen J. Meltzer and Stephen B. Baylin and James G. Herman},
  journal={Cancer research},
  volume={60 16},
Germ-line mutations in the tumor suppressor gene APC are associated with hereditary familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic colorectal tumors. We now report that methylation in the promoter region of this gene constitutes an alternative mechanism for gene inactivation in colon and other tumors of the gastrointestinal tract. The APC promoter is hypermethylated in 18% of primary sporadic colorectal carcinomas (n = 108) and adenoma (n = 48), and neoplasia… CONTINUE READING
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Hypermethylation - associated inactivation of p 14 ARF is independent of p 16 INK 4 a methylation and p 53 mutational status

  • M. Esteller, S. R. Hamilton, P. C. Burger, S. B. Baylin, J. G. Herman
  • Cancer Res .
  • 2000

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