Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism.

Abstract

Alzheimer's is a neurodegenerative disease. Its symptoms are attributed to a deficiency of cholinergic neurotransmission. The drugs of choice for the treatment of Alzheimer's disease are acetylcholinesterase (AChE) inhibitors. Starting in the 1980's from non-specific AChE inhibitors, the first-generation drugs such as physostigmine, a second generation of… (More)
DOI: 10.1002/bmc.1573

Topics

16 Figures and Tables

Cite this paper

@article{Marques2011AnalysisOA, title={Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism.}, author={Lygia Azevedo Marques and Martin Giera and Henk Lingeman and Wilfried Ma Niessen}, journal={Biomedical chromatography : BMC}, year={2011}, volume={25 1-2}, pages={278-99} }