Analysis of a recombination hotspot for gene conversion occurring at the HIS2 gene of Saccharomyces cerevisiae.

@article{Malone1994AnalysisOA,
  title={Analysis of a recombination hotspot for gene conversion occurring at the HIS2 gene of Saccharomyces cerevisiae.},
  author={Robert E. Malone and S Kim and Steven A. Bullard and Stefan Lundquist and L Hutchings-Crow and S Cramton and Linda L. Lutfiyya and Jong Lee},
  journal={Genetics},
  year={1994},
  volume={137 1},
  pages={5-18}
}
The properties of gene conversion as measured in fungi that generate asci containing all the products of meiosis imply that meiotic recombination initiates at specific sites. The HIS2 gene of Saccharomyces cerevisiae displays a high frequency of gene conversion, indicating that it is a recombination hotspot. The HIS2 gene was cloned and sequenced, and the cloned DNA was used to make several different types of alterations in the yeast chromosome by transformation; these alterations were used to… CONTINUE READING

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Molecular Evolution of hisB Genes

Journal of Molecular Evolution • 2003
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