Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization

@article{WickiStordeur2013AnalysisOA,
  title={Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization},
  author={Leigh E Wicki-Stordeur and Andrew K.J. Boyce and Leigh Anne Swayne},
  journal={Cell Communication \& Adhesion},
  year={2013},
  volume={20},
  pages={73 - 79}
}
Abstract Pannexins (Panxs) are a three-member family of large pore ion channels permeable to ions and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus plays an important role in channel trafficking. Panx2, another family member, has a longer and highly dissimilar C-terminus. Interestingly, Panx1 is readily found at the plasma membrane, while Panx2 is mainly present on intracellular membranes. Here we used overlap-extension cloning to create the first chimeric Panx… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Functional assays in cultured cells transiently expressing Panx1 and Panx3 were incapable of forming intercellular channels, but assembled into functional cell surface channels, showing that these proteins probably play an important biological role as single membrane channels. Expand
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TLDR
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TLDR
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TLDR
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