Analysis of a human tumor-associated glycoprotein (TAG-72) identified by monoclonal antibody B72.3.

@article{Johnson1986AnalysisOA,
  title={Analysis of a human tumor-associated glycoprotein (TAG-72) identified by monoclonal antibody B72.3.},
  author={Verne G Johnson and Jeffrey Schlom and Andrew W J Paterson and John Bennett and John L. Magnani and David Colcher},
  journal={Cancer research},
  year={1986},
  volume={46 2},
  pages={850-7}
}
Monoclonal antibody B72.3 binds a high-molecular-weight tumor-associated glycoprotein identified as TAG-72. This study reports the partial purification and characterization of TAG-72 from a xenograft of a human carcinoma cell line, LS-174T, which expresses high levels of this antigen. The tumor homogenate was initially fractionated by Sepharose CL-4B chromatography. The high-molecular-weight TAG-72, found in the exclusion volume, was then subjected to two sequential passages through B72.3… CONTINUE READING
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Use of monoclonal antibody (B72.3) as an ¡mmunocytochemical adjunct to diagnosis of adenocarcinoma in human effusions

  • W. W. Johnson, C. A. Szpak, C. Lottich, A. Thor, J. Schlom
  • Cancer Res.,
  • 1985
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