Analysis of a histone H2A variant from fission yeast: evidence for a role in chromosome stability

@article{Carr1994AnalysisOA,
  title={Analysis of a histone H2A variant from fission yeast: evidence for a role in chromosome stability},
  author={Antony M. Carr and S M Dorrington and J. Hindley and Geraldine A. Phear and Stephen J Aves and Paul Nurse},
  journal={Molecular and General Genetics MGG},
  year={1994},
  volume={245},
  pages={628-635}
}
We have isolated and characterised the pht1 gene from the fission yeast Schizosaccharomyces pombe. The sequence of the predicted translation product has revealed a striking similarity to the family of H2A.F/Z histone variant proteins, which have been found in a variety of different organisms. Cells deleted for the pht1 gene locus grow slowly, exhibit an altered colony morphology, increased resistance to heat shock and show a significant decrease in the fidelity of segregation of an S. pombe… CONTINUE READING

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