Analysis of a high-throughput HLA antibody screening assay for use with platelet donors.

@article{Fadeyi2008AnalysisOA,
  title={Analysis of a high-throughput HLA antibody screening assay for use with platelet donors.},
  author={Emmanuel A. Fadeyi and Sharon Kay Adams and Brett M Peterson and Julia Hackett and Phyllis J Byrne and Harvey G. Klein and Francesco M. Marincola and Susan F. Leitman and David F Stroncek},
  journal={Transfusion},
  year={2008},
  volume={48 6},
  pages={
          1174-9
        }
}
BACKGROUND Passive infusion of HLA antibodies has been implicated in transfusion reactions. A rapid, inexpensive method of screening blood donors for HLA antibodies might reduce the incidence of reactions. A high-throughput microbead-flow analyzer HLA antibody detection technique was compared with an enzyme-linked immunosorbent assay (ELISA) method. STUDY DESIGN AND METHODS Ninety-six apheresis platelet (PLT) donors were tested for antibodies to Class I and II HLA antigens with mixed-antigen… CONTINUE READING
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