Analysis of a heme-dependent signal transduction system in Corynebacterium diphtheriae: deletion of the chrAS genes results in heme sensitivity and diminished heme-dependent activation of the hmuO promoter.

@article{Bibb2005AnalysisOA,
  title={Analysis of a heme-dependent signal transduction system in Corynebacterium diphtheriae: deletion of the chrAS genes results in heme sensitivity and diminished heme-dependent activation of the hmuO promoter.},
  author={Lori A. Bibb and Natalie D. King and Carey A. Kunkle and Michael P. Schmitt},
  journal={Infection and immunity},
  year={2005},
  volume={73 11},
  pages={7406-12}
}
The Corynebacterium diphtheriae hmuO gene encodes a heme oxygenase that is involved in the utilization of heme as an iron source. Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme-dependent transcriptional activation of an hmuO promoter-lacZ fusion was dependent on the cloned C. diphtheriae chrA and chrS genes (chrAS), which encode the response regulator and sensor kinase, respectively, of a two… CONTINUE READING

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Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme - dependent transcriptional activation of an hmuO promoter - lacZ fusion was dependent on the cloned C. diphtheriae chrA and chrS genes ( chrAS ) , which encode the response regulator and sensor kinase , respectively , of a two - component signal transduction system .
Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme - dependent transcriptional activation of an hmuO promoter - lacZ fusion was dependent on the cloned C. diphtheriae chrA and chrS genes ( chrAS ) , which encode the response regulator and sensor kinase , respectively , of a two - component signal transduction system .
Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme - dependent transcriptional activation of an hmuO promoter - lacZ fusion was dependent on the cloned C. diphtheriae chrA and chrS genes ( chrAS ) , which encode the response regulator and sensor kinase , respectively , of a two - component signal transduction system .
Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme - dependent transcriptional activation of an hmuO promoter - lacZ fusion was dependent on the cloned C. diphtheriae chrA and chrS genes ( chrAS ) , which encode the response regulator and sensor kinase , respectively , of a two - component signal transduction system .
Transcription, GeneticBiological process results from biological processTranscriptional Activation
Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme - dependent transcriptional activation of an hmuO promoter - lacZ fusion was dependent on the cloned C. diphtheriae chrA and chrS genes ( chrAS ) , which encode the response regulator and sensor kinase , respectively , of a two - component signal transduction system .
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