Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history.

@article{Murata1996AnalysisOA,
  title={Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history.},
  author={Motoi Murata and Mariko Tagawa and Misa Kimura and Hiromi Kimura and Shun-ichi Watanabe and Hiromitsu Saisho},
  journal={Carcinogenesis},
  year={1996},
  volume={17 2},
  pages={261-4}
}
The p53 tumor suppressor gene is often mutated in various human cancers and a common polymorphism is known at codon 72 of exon 4, with two alleles encoding either arginine (CGC) or proline (CCC). Association of this polymorphism with any human cancer susceptibility has yet to be clarified. We have conducted a case-control study in Japan on the distribution of the three genotypes with 191 lung cancer patients, 152 control patients with non-cancerous pulmonary diseases and 115 colorectal cancer… CONTINUE READING