Analysis of a clonally related mantle cell and Hodgkin lymphoma indicates Epstein-Barr virus infection of a Hodgkin/Reed-Sternberg cell precursor in a germinal center.

@article{Tinguely2003AnalysisOA,
  title={Analysis of a clonally related mantle cell and Hodgkin lymphoma indicates Epstein-Barr virus infection of a Hodgkin/Reed-Sternberg cell precursor in a germinal center.},
  author={Marianne Tinguely and Richard Rosenquist and Christer Sundstr{\"o}m and Rose-Marie Amini and Ralf K{\"u}ppers and Martin-Leo Hansmann and Andreas Braeuninger},
  journal={The American journal of surgical pathology},
  year={2003},
  volume={27 11},
  pages={1483-8}
}
The simultaneous occurrence of a Hodgkin lymphoma (HL) and a non-Hodgkin lymphoma (NHL) is a rare event, and single cell analyses of such composite lymphomas revealed that NHL and Hodgkin/Reed-Sternberg (HRS) tumor cells are frequently descendants of the same tumor clone precursors. Here we present a composite lymphoma consisting of a mantle cell lymphoma… CONTINUE READING