Analysis of a RanGTP-regulated gradient in mitotic somatic cells

@article{Kalab2006AnalysisOA,
  title={Analysis of a RanGTP-regulated gradient in mitotic somatic cells},
  author={P. Kalab and Arnd Pralle and E. Isacoff and R. Heald and K. Weis},
  journal={Nature},
  year={2006},
  volume={440},
  pages={697-701}
}
The RanGTPase cycle provides directionality to nucleocytoplasmic transport, regulating interactions between cargoes and nuclear transport receptors of the importin-β family. The Ran–importin-β system also functions in mitotic spindle assembly and nuclear pore and nuclear envelope formation. The common principle underlying these diverse functions throughout the cell cycle is thought to be anisotropy of the distribution of RanGTP (the RanGTP gradient), driven by the chromatin-associated guanine… Expand
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References

SHOWING 1-10 OF 19 REFERENCES
Crm1 is a mitotic effector of Ran-GTP in somatic cells
The Ran GTPase regulates kinetochore function.
Importin beta: conducting a much larger cellular symphony.
A systems analysis of importin-α–β mediated nuclear protein import
...
1
2
...