Analysis of a RanGTP-regulated gradient in mitotic somatic cells

@article{Kalb2006AnalysisOA,
  title={Analysis of a RanGTP-regulated gradient in mitotic somatic cells},
  author={Petr Kal{\'a}b and Arnd Pralle and Ehud Y Isacoff and Rebecca Heald and Karsten Weis},
  journal={Nature},
  year={2006},
  volume={440},
  pages={697-701}
}
The RanGTPase cycle provides directionality to nucleocytoplasmic transport, regulating interactions between cargoes and nuclear transport receptors of the importin-β family. The Ran–importin-β system also functions in mitotic spindle assembly and nuclear pore and nuclear envelope formation. The common principle underlying these diverse functions throughout the cell cycle is thought to be anisotropy of the distribution of RanGTP (the RanGTP gradient), driven by the chromatin-associated guanine… CONTINUE READING
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