Analysis of Whole Skeleton 3H-Tetracycline Loss as a Measure of Bone Resorption in Maturing Rats

@article{Demoss1997AnalysisOW,
  title={Analysis of Whole Skeleton 3H-Tetracycline Loss as a Measure of Bone Resorption in Maturing Rats},
  author={Daniel Demoss and Gary L. Wright},
  journal={Calcified Tissue International},
  year={1997},
  volume={61},
  pages={412-417}
}
Several modifications of the 3H-tetracycline bone labeling method for measuring whole skeleton bone resorption were tested. Under steady state conditions of whole skeleton resorptive activity, bone labeling for intervals longer than 2 weeks prior to experimentation did not significantly alter the urinary 3H-tetracycline loss curve. The utilization of nonlinear regression analysis showed that the urinary loss of 3H-tetracycline was best described by double exponential equations, indicating the… CONTINUE READING

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