Analysis of VEGF, Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progression.

@article{Hlobilkova2009AnalysisOV,
  title={Analysis of VEGF, Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progression.},
  author={A Hlobilkova and Jiř{\'i} Ehrmann and Petra Knizetova and V Krejci and Ondřej Kalita and Z Kolar},
  journal={Neoplasma},
  year={2009},
  volume={56 4},
  pages={284-90}
}
  • A Hlobilkova, Jiří Ehrmann, +3 authors Z Kolar
  • Published 2009 in Neoplasma
Astrocytomas, particularly high grade astrocytoma, are brain tumors with potent angiogenic activity. Our immnunohistochemical study assessed vascular endothelial growth factor (VEGF), VEGF receptors (Flk-1, and Flt-1), the intermediate filamental protein nestin which plays a role in central nervous system development, and MMP-9, which belongs the family of matrix metalloproteinases implicated in tumor invasion and angiogenesis regulation. We investigated the expression of VEGF, its receptors… CONTINUE READING

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