Analysis of Tyrosine Kinase Signaling in Human Cancer by Stable Isotope Labeling with Heavy Amino Acids in Mouse Xenografts Utilizing Mouse Express ® Lysine 13 C 6 Mouse Feed

Abstract

Tyrosine kinases (TK) play important roles in the induction of cell growth, survival and migration. They also have oncogenic activity when deregulated, a role originally described for the constitutively active v-SRC1 and since then, observed with most TK in human cancer.2 A large body of evidence indicates that aberrant TK activities contributes to cancer… (More)

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