Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

@article{CarcamoOrive2017AnalysisOT,
  title={Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.},
  author={Ivan Carcamo-Orive and Gabriel E. Hoffman and Paige E Cundiff and Noam D. Beckmann and Sunita L d'Souza and Joshua W. Knowles and Achchhe Lal Patel and Dimitri Papatsenko and Fahim A. Abbasi and Gerald Mark Reaven and Sean Whalen and Philip S. Lee and Mohammad Shahbazi and Marc Henrion and Kuixi Zhu and Sven Wang and Panos Roussos and Eric E. Schadt and Gaurav Pandey and Rui Chang and Thomas Quertermous and Ihor Lemischka},
  journal={Cell stem cell},
  year={2017},
  volume={20 4},
  pages={
          518-532.e9
        }
}
Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease modeling and regenerative medicine. We have used RNA-sequencing analysis and linear mixed models to examine the sources of gene expression variability in 317 human iPSC lines from 101 individuals. We found that ∼50% of genome-wide expression variability is explained by… CONTINUE READING

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