Analysis of Transcriptional Regulation of the Human miR-17-92 Cluster; Evidence for Involvement of Pim-1

@inproceedings{Thomas2013AnalysisOT,
  title={Analysis of Transcriptional Regulation of the Human miR-17-92 Cluster; Evidence for Involvement of Pim-1},
  author={Maren Thomas and Kerstin Lange-Gr{\"u}nweller and Dorothee Hartmann and Lara Golde and Julia Schlereth and Dennis Streng and Achim Aigner and Arnold Gr{\"u}nweller and Roland K. Hartmann},
  booktitle={International journal of molecular sciences},
  year={2013}
}
The human polycistronic miRNA cluster miR-17-92 is frequently overexpressed in hematopoietic malignancies and cancers. Its transcription is in part controlled by an E2F-regulated host gene promoter. An intronic A/T-rich region directly upstream of the miRNA coding region also contributes to cluster expression. Our deletion analysis of the A/T-rich region revealed a strong dependence on c-Myc binding to the functional E3 site. Yet, constructs lacking the 5'-proximal ~1.3 kb or 3'-distal ~0.1 kb… CONTINUE READING
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