Analysis of TAp73-dependent signaling via omics technologies.

  title={Analysis of TAp73-dependent signaling via omics technologies.},
  author={Angelo D'Alessandro and Cristina Marrocco and Sara Rinalducci and Angelo Peschiaroli and Anna Maria Timperio and Lucilla Bongiorno-Borbone and Alessandro Finazzi Agr{\`o} and Gerry Melino and Lello Zolla},
  journal={Journal of proteome research},
  volume={12 9},
Transactivation-proficient (TA) p73 is a transcription factor belonging to the p53 family, which regulates a variety of biological processes, including neurogenesis, differentiation, apoptosis, and DNA damage checkpoint response. In the present study, we adopted multiple Omics approaches, based upon the simultaneous application of metabolomics, lipidomics, and proteomics, in order to dissect the intracellular pathways activated by p73. As cellular model, we utilized a clone of the human… CONTINUE READING
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