Analysis of T lymphocytes after bone marrow transplantation using monoclonal antibodies.

@article{Fox1982AnalysisOT,
  title={Analysis of T lymphocytes after bone marrow transplantation using monoclonal antibodies.},
  author={Richard I Fox and Robert McMillan and W. E. Spruce and Patricia Tani and David P. Mason},
  journal={Blood},
  year={1982},
  volume={60 3},
  pages={578-82}
}
Using monoclonal antibodies to cell surface antigens and fluorescent cell sorter analysis, we studied peripheral blood lymphocyte subsets after bone marrow transplantation (BMT). In 13 patients studied 3 mo or more after BMT, the ratio of T-cell subsets defined by antibodies OKT4 and OKT8 was reversed (OKT4/OK%8 = 0.7 +/- 0.3) in comparison to normal volunteers or bone marrow donors (ratio OKT4/OKT8 = 1.7 +/- 0.4) (p less than 0.001). This reversed ratio persisted for up to 3 yr after BMT. In… CONTINUE READING
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