Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3

@article{Gold1991AnalysisOT,
  title={Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3},
  author={Daniel P. Gold and Halina Offner and Daye Sun and Sandra Wiley and Arthur A. Vandenbark and Darcy B. Wilson},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={174},
  pages={1467 - 1476}
}
This study explores the usage of T cell antigen receptor (TCR) beta chain elements in Lewis rats with experimentally induced allergic encephalomyelitis (EAE). TCRs from 15 different T cell clones and hybridomas derived from animals immunized with myelin basic protein (MBP), and all having specificity for the 21-mer encephalitogenic fragment MBP 68-88, utilized V beta 8.2. In addition, there was a marked conservation of the first two amino acid residues of the junctional complementarity… CONTINUE READING

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