Analysis of Signalling Pathways Using Continuous Time Markov Chains

Abstract

We describe a quantitative modelling and analysis approach for signal transduction networks. We illustrate the approach with an example, the RKIP inhibited ERK pathway [CSK03]. Our models are high level descriptions of continuous time Markov chains: proteins are modelled by synchronous processes and reactions by transitions. Concentrations are modelled by… (More)
DOI: 10.1007/11880646_3

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