Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomerase.

@article{Potterf2001AnalysisOS,
  title={Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomerase.},
  author={S. Brian Potterf and Ramin Mollaaghababa and Li Hou and E. Michelle Southard-Smith and Thomas J. Hornyak and Heinz Arnheiter and William J. Pavan},
  journal={Developmental biology},
  year={2001},
  volume={237 2},
  pages={245-57}
}
SOX10 is a high-mobility-group transcription factor that plays a critical role in the development of neural crest-derived melanocytes. At E11.5, mouse embryos homozygous for the Sox10(Dom) mutation entirely lack neural crest-derived cells expressing the lineage marker KIT, MITF, or DCT. Moreover, neural crest cell cultures derived from homozygous embryos do not give rise to pigmented cells. In contrast, in Sox10(Dom) heterozygous embryos, melanoblasts expressing KIT and MITF do occur, albeit in… CONTINUE READING

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