Analysis of SDF-1/CXCR4 signaling in primordial germ cell migration and survival or differentiation in Xenopus laevis

@article{Takeuchi2010AnalysisOS,
  title={Analysis of SDF-1/CXCR4 signaling in primordial germ cell migration and survival or differentiation in Xenopus laevis},
  author={Tomoyo Takeuchi and Yoko Tanigawa and Ryohei Minamide and Kohji Ikenishi and Tohru Komiya},
  journal={Mechanisms of Development},
  year={2010},
  volume={127},
  pages={146-158}
}
Directional migration of primordial germ cells (PGCs) toward future gonads is a common feature in many animals. In zebrafish, mouse and chicken, SDF-1/CXCR4 chemokine signaling has been shown to have an important role in PGC migration. In Xenopus, SDF-1 is expressed in several regions in embryos including dorsal mesoderm, the target region that PGCs migrate to. CXCR4 is known to be expressed in PGCs. This relationship is consistent with that of more well-known animals. Here, we present… CONTINUE READING

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