Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age.

@article{Kirk1998AnalysisOR,
  title={Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age.},
  author={Christopher J. Kirk and Richard L. Miller},
  journal={Cellular immunology},
  year={1998},
  volume={190 1},
  pages={33-42}
}
Stimulation of the ERK (MAPK) pathway in T-lymphocytes contributes to cell activation and IL-2 production. The ERK pathway is initiated by the activation of the serine/threonine kinase Raf-1 in a Ras-dependent manner. Raf-1 activates the dual-specific kinase MEK, which in turn activates ERK. To see if aging leads to an alteration of Raf-1 kinase activity we performed in vitro kinase assays on Raf-1 isolated from CD4(+) T-cells from young and old mice. We found an age-related impairment in the… CONTINUE READING
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