Analysis of RT sequences of subtype C HIV-type 1 isolates from indian patients at failure of a first-line treatment according to clinical and/or immunological WHO guidelines.

@article{Deshpande2010AnalysisOR,
  title={Analysis of RT sequences of subtype C HIV-type 1 isolates from indian patients at failure of a first-line treatment according to clinical and/or immunological WHO guidelines.},
  author={Alaka K. Deshpande and Anne C{\'e}cile Jeannot and Marie H{\'e}l{\`e}ne Schrive and Linda Wittkop and Patricia Recordon Pinson and H{\'e}rv{\'e} Fleury},
  journal={AIDS research and human retroviruses},
  year={2010},
  volume={26 3},
  pages={343-50}
}
The reverse transcriptase (RT) sequences of HIV-1 subtype C isolates from Indian patients at failure (according to WHO clinical or immunological criteria) of a first-line treatment including d4T/AZT-3TC-NVP/EFV were compared to those of HIV-1 isolates from naive patients and analyzed for drug resistance mutations (DRMs), which were interpreted according to ANRS and Stanford algorithms. All viruses were of subtype C. We have observed a decrease of the polymorphism at positions 36 and 214 of RT… CONTINUE READING