Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.

@article{Jiang2006AnalysisOR,
  title={Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.},
  author={Zhong Yi Jiang and Peigou G. Chu and Bruce A. Woda and Kenneth L. Rock and Jingjing Liu and Chung-Cheng Hsieh and Cuizhen Li and Wengang Chen and Hai Ou Duan and Scott McDougal and Chin-lee Wu},
  journal={The Lancet. Oncology},
  year={2006},
  volume={7 7},
  pages={556-64}
}
BACKGROUND Distant metastasis is the main cause of death from renal-cell carcinoma, and the metastatic potential of tumours is often unpredictable. We aimed to investigate whether IMP3, an oncofetal RNA-binding protein, can be used as a biomarker to predict metastasis and prognosis of renal-cell carcinoma. METHODS We studied 501 primary and metastatic renal-cell tumours. 371 patients with localised primary tumours were further investigated by use of survival analysis. We assessed IMP3… CONTINUE READING

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