Analysis of R213R and 13494 g→a polymorphisms of the p53 gene in individuals with esophagitis, intestinal metaplasia of the cardia and Barrett’s Esophagus compared with a control group

@inproceedings{Pilger2007AnalysisOR,
  title={Analysis of R213R and 13494 g→a polymorphisms of the p53 gene in individuals with esophagitis, intestinal metaplasia of the cardia and Barrett’s Esophagus compared with a control group},
  author={Diogo Andr{\'e} Pilger and Patr{\'i}cia Luciana da Costa Lopez and F{\^a}bio Segal and Sandra Leistner-Segal},
  booktitle={Genomic Medicine},
  year={2007}
}
Protein p53 is the tumor suppressor involved in cell cycle control and apoptosis. There are several polymorphisms reported for p53 which can affect important regions involved in protein tumor suppressor activity. Amongst the polymorphisms described, R213R and 13949 g→a are rarely studied, with an estimate frequency not yet available for the Brazilian population. The purpose of this study was to investigate the genotype and allele frequencies and associations of these polymorphisms in a group of… CONTINUE READING
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