Analysis of Prion Strains by PrPSc Profiling in Sporadic Creutzfeldt–Jakob Disease

@article{Schoch2006AnalysisOP,
  title={Analysis of Prion Strains by PrPSc Profiling in Sporadic Creutzfeldt–Jakob Disease},
  author={Gaby Schoch and Harald Seeger and Julien Ed Bogousslavsky and Markus Tolnay and Robert Charles Janzer and Adriano Aguzzi and Markus Glatzel},
  journal={PLoS Medicine},
  year={2006},
  volume={3},
  pages={13363 - 13383}
}
BACKGROUND Prion diseases are a group of invariably fatal neurodegenerative disorders affecting humans and a wide range of mammals. An essential part of the infectious agent, termed the prion, is composed of an abnormal isoform (PrPSc) of a host-encoded normal cellular protein (PrPC). The conversion of PrPC to PrPSc is thought to play a crucial role in the development of prion diseases and leads to PrPSc deposition, mainly in the central nervous system. Sporadic Creutzfeldt-Jakob disease (sCJD… CONTINUE READING