Analysis of Pneumocystis jirovecii DHPS alleles implicated in sulfamethoxazole resistance using an Escherichia coli model system.

@article{Iliades2005AnalysisOP,
  title={Analysis of Pneumocystis jirovecii DHPS alleles implicated in sulfamethoxazole resistance using an Escherichia coli model system.},
  author={P. Iliades and Steven Richard Meshnick and Ian G Macreadie},
  journal={Microbial drug resistance},
  year={2005},
  volume={11 1},
  pages={1-8}
}
Pneumocystis jirovecii is a major opportunistic pathogen that causes Pneumocystis pneumonia (PCP). Drug treatment failure has been associated epidemiologically with point mutations in the gene for dihydropteroate synthase which is part of a gene that encodes three covalently linked enzymes involved in folic acid synthesis (FAS). The evaluation of whether… CONTINUE READING