Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.

@article{Kuropka2015AnalysisOP,
  title={Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.},
  author={Benno Kuropka and Amelie Witte and Jana Sticht and Natalie Waldt and Paul Majkut and Christian P R Hackenberger and Burkhart Schraven and Eberhard Krause and Stefanie Kliche and Christian Freund},
  journal={Molecular & cellular proteomics : MCP},
  year={2015},
  volume={14 11},
  pages={2961-72}
}
Stimulation of T cells leads to distinct changes of their adhesive and migratory properties. Signal propagation from activated receptors to integrins depends on scaffolding proteins such as the adhesion and degranulation promoting adaptor protein (ADAP)(1). Here we have comprehensively investigated the phosphotyrosine interactome of ADAP in T cells and define known and novel interaction partners of functional relevance. While most phosphosites reside in unstructured regions of the protein… CONTINUE READING