Analysis of Pathogenicity and Virulence Factors of Ageratum leaf curl Sichuan virus

@article{Li2020AnalysisOP,
  title={Analysis of Pathogenicity and Virulence Factors of Ageratum leaf curl Sichuan virus},
  author={Pengbai Li and Chenchen Jing and Hongyan Ren and Zhou Jia and Hussein Ghanem and Gentu Wu and Mingjun Li and Ling Qing},
  journal={Frontiers in Plant Science},
  year={2020},
  volume={11}
}
Ageratum leaf curl Sichuan virus (ALCScV) is a novel monopartite begomovirus, which was identified from Ageratum conyzoides plants in Sichuan Province, China. In this study, we showed that ALCScV can induce typical dwarf and downward leaf-curling symptoms in Ageratum conyzoides, Helianthus annuus, and Nicotiana benthamiana plants and that the noncognate betasatellite can enhance disease symptoms and increase viral accumulation. Expression of the ALCScV-encoded V2, C1, and C4 proteins through a… 

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References

SHOWING 1-10 OF 62 REFERENCES
Infectivity of Euphorbia leaf curl virus and interaction with Tomato yellow leaf curl China betasatellite
TLDR
This is the first report about a monopartite begomovirus that has been reintroduced into a plant of the genus Euphorbia and it is suggested that this virus was reintroduced as a result of insect transmission from agro-infected P. hybrida as a source.
Molecular identification of tobacco leaf curl disease in Sichuan province of China
TLDR
Co-infection of TYLCCNV and PaLCuCNV was identified in tobacco plants with typical symptoms of TLCD from Sichuan province in China, and this is the first report of PaLCUCNV infecting tobacco in China.
The Malvastrum Yellow Vein Virus C4 Protein Promotes Disease Symptom Development and Enhances Virus Accumulation in Plants
TLDR
The results indicate that the MaYVV C4 protein is a determinant of disease symptom and viral DNA accumulation and this protein can also function as a suppressor of RNA silencing and alter cell division and expansion.
Molecular and biological characterization of Chilli leaf curl virus and associated Tomato leaf curl betasatellite infecting tobacco in Oman
TLDR
The leaf curl disease of tobacco in Oman was shown to be caused by ChiLCV and ToLCB, the first identification of Chi LCV with ToLC B infecting tobacco.
The AC4 Protein of a Cassava Geminivirus Is Required for Virus Infection.
TLDR
Results show involvement of EACMCV AC4 in virus infectivity; they also suggest a role for the combined action of mutation and selection, under prevailing environmental conditions, on begomovirus genetic variation and diversity.
Complete nucleotide sequence of a novel monopartite begomovirus infecting Ageratum conyzoides in China
TLDR
Two isolates of a novel monopartite begomovirus were obtained from naturally infected Ageratum conyzoides plants showing typical leaf curling and enation symptoms in Sichuan Province, China, and the tentative name “ageratum leaf curl Sicuan virus” (ALCScV) is proposed.
Involvement of C4 Protein of Beet Severe Curly Top Virus (Family Geminiviridae) in Virus Movement
TLDR
The results suggest that C4 protein in BSCTV is involved in symptom production and may facilitate virus movement instead of virus replication.
Functional Scanning of Apple Geminivirus Proteins as Symptom Determinants and Suppressors of Posttranscriptional Gene Silencing
TLDR
Functional scanning of apple geminivirus proteins as symptom determinants and suppressors of posttranscriptional gene silencing (PTGS) indicated that AGV V2 is an important virulence factor localized to the nucleus and cytoplasm that suppresses PTGS and induces severe symptoms of crinkling and necrosis.
C4 protein of Beet severe curly top virus is a pathomorphogenetic factor in Arabidopsis
TLDR
Results suggest that the Curtovirus C4 proteins are involved actively in host cell-cycle regulation to recruit host factors for virus replication and symptom development.
Multifaceted role of geminivirus associated betasatellite in pathogenesis
TLDR
The molecular aspects of the pathogenesis of betasatellites, including various βC1‐host factor interactions and their effects on the suppression of defence responses of the plants are discussed.
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