Analysis of PIK3CA and B-RAF gene mutations in human astrocytomas: association with activation of ERK and AKT.

Abstract

OBJECTIVE The analysis of the presence of PIK3CA and B-RAF gene mutations in relation to ERK and AKT activation in diffusely infiltrating astrocytomas, in order to determine their potential role in tumor aggressiveness. METHODS Polymerase chain reaction-single strand confirmation polymorphism (PCR-SSCP) and sequencing analysis were used for PIK3CA and B… (More)

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@article{ElHabr2010AnalysisOP, title={Analysis of PIK3CA and B-RAF gene mutations in human astrocytomas: association with activation of ERK and AKT.}, author={E A El-Habr and P Tsiorva and Maria Theodorou and Georgia Levidou and Penelope Korkolopoulou and Georgios Vretakos and Lillian Petraki and Nikolaos Michalopoulos and Efstratios S. Patsouris and Angelica A. Saetta}, journal={Clinical neuropathology}, year={2010}, volume={29 4}, pages={239-45} }