Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases.

@article{Rafty2002AnalysisOO,
  title={Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases.},
  author={Louise A. Rafty and Manning T Schmidt and Anne-Laure L Perraud and Andrew M Scharenberg and John M Denu},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 49},
  pages={47114-22}
}
The Sir2 family of NAD(+)-dependent histone/protein deacetylases has been implicated in a wide range of biological activities, including gene silencing, life span extension, and chromosomal stability. Recent evidence has indicated that these proteins produce a novel metabolite O-acetyl-ADP-ribose (OAADPr) during deacetylation. Cellular studies have demonstrated that this metabolite exhibits biological effects when microinjected in living cells. However, the molecular targets of OAADPr remain to… CONTINUE READING