Analysis of Non-Typeable Haemophilous influenzae VapC1 Mutations Reveals Structural Features Required for Toxicity and Flexibility in the Active Site

@article{Hamilton2014AnalysisON,
  title={Analysis of Non-Typeable Haemophilous influenzae VapC1 Mutations Reveals Structural Features Required for Toxicity and Flexibility in the Active Site},
  author={Brooke Hamilton and Alexander Manzella and Karyn M. Schmidt and V. DiMarco and J. Butler},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
  • Brooke Hamilton, Alexander Manzella, +2 authors J. Butler
  • Published 2014
  • Biology, Medicine
  • PLoS ONE
  • Bacteria have evolved mechanisms that allow them to survive in the face of a variety of stresses including nutrient deprivation, antibiotic challenge and engulfment by predator cells. A switch to dormancy represents one strategy that reduces energy utilization and can render cells resistant to compounds that kill growing bacteria. These persister cells pose a problem during treatment of infections with antibiotics, and dormancy mechanisms may contribute to latent infections. Many bacteria… CONTINUE READING
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