• DOI:10.1371/journal.pone.0112921
Corpus ID: 9939257

Analysis of Non-Typeable Haemophilous influenzae VapC1 Mutations Reveals Structural Features Required for Toxicity and Flexibility in the Active Site

@article{Hamilton2014AnalysisON,
  title={Analysis of Non-Typeable Haemophilous influenzae VapC1 Mutations Reveals Structural Features Required for Toxicity and Flexibility in the Active Site},
  author={Brooke Hamilton and Alexander Manzella and Karyn M. Schmidt and V. DiMarco and J. Butler},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}

Brooke Hamilton, Alexander Manzella, +2 authors J. Butler

Published 2014

Biology, Medicine

PLoS ONE

Bacteria have evolved mechanisms that allow them to survive in the face of a variety of stresses including nutrient deprivation, antibiotic challenge and engulfment by predator cells. A switch to dormancy represents one strategy that reduces energy utilization and can render cells resistant to compounds that kill growing bacteria. These persister cells pose a problem during treatment of infections with antibiotics, and dormancy mechanisms may contribute to latent infections. Many bacteria… CONTINUE READING

View PDF

Save to Library

Create Alert

Cite

Launch Research Feed