Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.

@article{Lallemand2005AnalysisOM,
  title={Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.},
  author={Yvan Lallemand and M. S. Nicola and Casto Ramos and Antoine Bach and C{\'e}cile Saint Cloment and B. Robert},
  journal={Development},
  year={2005},
  volume={132 13},
  pages={3003-14}
}
The homeobox-containing genes Msx1 and Msx2 are highly expressed in the limb field from the earliest stages of limb formation and, subsequently, in both the apical ectodermal ridge and underlying mesenchyme. However, mice homozygous for a null mutation in either Msx1 or Msx2 do not display abnormalities in limb development. By contrast, Msx1; Msx2 double mutants exhibit a severe limb phenotype. Our analysis indicates that these genes play a role in crucial processes during limb morphogenesis… CONTINUE READING
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