Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles.

@article{Prunotto2004AnalysisOM,
  title={Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles.},
  author={Chiara Prunotto and Tiziana Crepaldi and Paolo E Forni and Alessandro Ieraci and Robert G. Kelly and Shahragim Tajbakhsh and M. Buckingham and Carola Ponzetto},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2004},
  volume={231 3},
  pages={582-91}
}
The Pax3 and c-met genes are necessary for the development of tongue, diaphragm, and limb muscles. These hypaxial muscles derive from precursors that migrate out of the ventrolateral lip of the somites at occipital, cervical, and limb levels. In this work, we re-examined primary myogenesis in c-met signaling mutants using a skeletal muscle-specific lacZ transgene (Mlc3f-nlacZ-2E). This strategy allowed us to identify precisely the shoulder, limb, tongue, and dermal muscles that need Met for… CONTINUE READING

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