Analysis of Maxi-K alpha subunit splice variants in human myometrium

  title={Analysis of Maxi-K alpha subunit splice variants in human myometrium},
  author={Michael Curley and John Joseph Morrison and Terry J Smith},
  journal={Reproductive biology and endocrinology : RB&E},
  pages={67 - 67}
BACKGROUND Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated in the modulation of human uterine contractions and myometrial Ca2+ homeostasis. However, the regulatory mechanism(s) governing the expression of Maxi-K channels with decreased calcium sensitivity at parturition are unclear. The objectives of this study were to investigate mRNA expression of the Maxi-K alpha subunit, and that of its splice variants, in human non-pregnant and pregnant myometrium, prior to… CONTINUE READING


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