Analysis of MUTYH genotypes and colorectal phenotypes in patients With MUTYH-associated polyposis.


BACKGROUND & AIMS Biallelic mutations in the base excision DNA repair gene MUTYH lead to MUTYH-associated polyposis (MAP) and predisposition to colorectal cancer (CRC). Functional studies have demonstrated significant differences in base recognition and glycosylase activity between various MUTYH mutations, notably for the 2 mutations most frequently… (More)
DOI: 10.1053/j.gastro.2008.10.056