Analysis of Lipid Metabolism in Brain of p 25 Transgenic Mouse-A Model of Alzheimer ’ s Disease

  • Srivathsan, Loh Sook Ling
  • Published 2008

Abstract

Alzheimer’s disease (AD) is an age-associated disorder that leads to neurocognitive impairment. Its main pathological hallmarks include amyloid beta (Aβ) plaques and hyperphosphorylated tau forming intracellular neurofibrillary tangles (NFT). Hyperactivation of a tau-phosphorylating protein, cdk5 by its activator p25 has been shown to be associated with AD… (More)

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