Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreas.


BACKGROUND Prognostic markers for pancreas cancer, such as CEA, CA19-9, ploidy analysis, and S-phase determination using flow cytometry, have not been consistently predictive. We chose to evaluate nuclear proliferation, as measured by the MIB-1 monoclonal antibody and digital image analysis, as a prognostic marker in pancreatic carcinoma, and compare the… (More)


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