Analysis of K-ras codon 12 mutations and p53 overexpression in colorectal nodule-aggregating tumors.

@article{Kusaka2000AnalysisOK,
  title={Analysis of K-ras codon 12 mutations and p53 overexpression in colorectal nodule-aggregating tumors.},
  author={Takashi Kusaka and Hirokazu Fukui and Yasushi Sano and Yoshihide Ueda and Tsutomu Chiba and Takahiro Fujimori},
  journal={Journal of gastroenterology and hepatology},
  year={2000},
  volume={15 10},
  pages={1151-7}
}
BACKGROUND AND AIMS Morphologically, colorectal nodule-aggregating tumors are quite different from polypoid-type colorectal tumors that develop via the adenoma-carcinoma sequence. Although polypoid-type colorectal tumors are well known to have a high incidence of K-ras gene mutation and p53 overexpression, colorectal nodule-aggregating tumors have not been… CONTINUE READING