Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.

@article{Couce1999AnalysisOK,
  title={Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.},
  author={Marta E. Couce and Diana M Bautista and Jose' Costa and David Carter},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={1999},
  volume={8 2},
  pages={71-9}
}
This study screened 11 samples of typical carcinoid (TC), 4 samples of atypical carcinoid (AC), 1 sample of large cell neuroendocrine carcinoma (LCNEC), and four metastases for point mutations in exons 5 to 8 of the p53 gene, and exons 1 and 2 of the K-ras. H-ras, and N-ras genes using polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) and direct sequencing and by immunohistochemistry for p53. Exon 1 of K-ras was mutated in two samples of low-grade AC and a… CONTINUE READING

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In conclusion , point mutations of the p53 gene were infrequent in these pulmonary neuroendocrine tumors , did not correlate in all samples with immunostaining , and were associated with the higher - grade tumors .
In conclusion , point mutations of the p53 gene were infrequent in these pulmonary neuroendocrine tumors , did not correlate in all samples with immunostaining , and were associated with the higher - grade tumors .
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